The Hand is the tragic story of a popular comic book artist that loses his drawing hand in a horrific accident. Jon Lansdale (Michael Caine) finds that after his hand was severed from his body, he is unable to continue his work as an artist. Moreover, his wife Anne (Andrea Marcovicci) is consumed with guilt after causing the accident, which begins to put a terrible strain on their marriage.
Jon was unable to locate his hand after it was cut from his body, despite thorough searching. The artist begins to hallucinate during what audiences are led to believe is a mental breakdown, as he sees different inanimate articles come to life and transform into his missing appendage.